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Reproductive Psychiatry Foe: Depakote

Updated: Jan 13, 2025

One of the very few medications we avoid in reproductive psychiatry is Depakote or Valproic Acid. It is a really great mood stabilizer medication, so don’t fret if you have to take it, but make sure to be on birth control (probably a barrier contraception too) and folic acid if you are a woman of reproductive age. That said, the rate of neural tube defects in babies exposed to Depakote is really high, about 1 in 50 to 1 in 100 (1-2%).


Depakote is a treatment option for bipolar disorder, migraines and seizures.


Posts are for education only. Please consult your healthcare provider before making any changes to your treatment plan.



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Tally Reproductive Psychiatrist, LLC

Private Practice of Jamie Sorenson, MD

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3689 Coolidge Court Unit 5

Tallahassee, FL 32311

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Call or Text: 850-694-2008

Fax: (786) 590-1485

Email: info@tallyrepropsych.com

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Online Scheduling:

https://tallyrepropsych.clientsecure.me/

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Conditions Dr. Sorenson has expertise in:

  • Attention Deficit Hyperactivity Disorder (ADHD)

  • Autism Spectrum Disorder (ASD)

  • Obsessive Compulsive Disorder (OCD)

  • Depression or Major Depressive Disorder (MDD)

  • Anxiety or Generalized Anxiety Disorder (GAD)

  • Panic Disorder with and without agorophobia

  • Bipolar Disorder

  • Bipolar 2 Disorder

  • Post Traumatic Stress Disorder (PTSD)

  • Chronic Post Traumatic Stress Disorder (CPTSD)

  • Premenstrual Dysphoric Disorder (PMDD) or Premenstrual Exacerbation of a mood disorder (PME)

  • Perinatal Depression and Postpartum Depression

  • Perinatal Anxiety and Postpartum Anxiety

  • Perinatal OCD and Postpartum OCD

  • Perinatal Psychosis and Postpartum Psychosis

  • Perimenopause/Menopause Mood and Anxiety Disorders

  • Perimenopause/Menopause Cognitive Disorders

  • Gender Dysphoria

  • LGBTQI Mental Health

  • Mood and anxiety disorders while undergoing infertility treatments

Comorbidities not directly treated by Dr. Sorenson that will routinely be considered in your individualized treatment plan and recommendations:

  • Ehlers-Danlos Syndrome

  • Hypermobility Spectrum Disorders

  • Mast Cell Activation Syndrome (MCAS)

  • Postural Orthostatic Tachycardia Syndrome (POTS), dysautonomia, and Mitral Valve Prolapse

  • Fibromyalgia 

  • Chronic Pain

  • Chronic Fatigue Syndrome (CFS)

  • Insomnia and Sleep Apnea

  • Narcolepsy and Idiopathic Hypersomnia

  • Chiari Malformation

  • Small Fiber Neuropathy

  • Pelvic organ prolapse, incontinence, chronic pelvic pain, pelvic floor dysfunction, hernias

  • Irritable Bowel Syndrome (IBS), gastroparesis, gut dysmotility

  • Bladder Pain Syndrome (previously interstitial cystitis)

  • Osteoporosis/Osteopenia

  • Dental Problems/TMJ

  • Migraines and Headaches​

  • Hormone Replacement Therapy (HRT)

  • Infertility Treatment

  • Endometriosis 

  • Polycystic Ovarian Syndrome (PCOS)

  • Thyroid Disorders: Hypothyroidism and Hyperthyroidism

  • Raynaud's Disease

  • Autoimmune disorders: Lupus (SLE), Sjogren's Syndrome, Hashimoto's thyroiditis and Grave's Disease, CREST Syndrome, Scleroderma, Celiac Disease and Ulcerative Colitis (UC), Psoriasis/Psoriatic Arthritis, Rheumatoid Arthritis (RA), Multiple Sclerosis (MS) and Neuromyelitis optica (NMO)

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