As estrogen levels begin to decrease, particularly during the transition into perimenopause, the candy neurons can become hyperactive, leading to a phenomenon often described as "hulked out." This hyperactivity means that the neurons can overreact to what would normally be considered minor triggers, resulting in sudden and intense sensations of heat known as hot flashes.

In the United States, research indicates that the peak earning potential for individuals typically occurs during their 40s and 50s. This is a critical period in one’s professional life, as it often coincides with significant career advancements and the accumulation of valuable experience. However, for many women, this peak earning phase aligns with the onset of perimenopause.