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Sertraline is not the only medication option available for pregnant and lactating women

Not sure who needs to hear this, but it is important to emphasize that sertraline is not the only medication option available for pregnant and lactating women. The landscape of psychiatric treatment during pregnancy is nuanced and requires careful consideration of the potential benefits and risks involved. In general, if a mother is stable on her current medication regimen prior to becoming pregnant, reproductive psychiatrists typically advocate for the continuation of that same medication. This approach is rooted in the understanding that maintaining stability in the mother's mental health is crucial not only for her well-being but also for the healthy development of the fetus. In fact, in the majority of cases, the prevailing practice is to keep the mother on her existing medication during pregnancy.


Baby with a pacifier stands in a crib, wearing a red and pink outfit. Soft light, colorful mobile overhead, peaceful mood.
A curious baby looks out from a crib, wearing a colorful outfit and a pacifier in a cozy nursery setting.

The reasoning behind this practice is multi-faceted and revolves around the potential risks associated with changing medications during such a critical period. Specifically, altering a mother's medication can lead to two significant new exposures for the developing fetus:


  • 1) Exposure to multiple psychotropic medications: When a medication is switched, it often leads to the introduction of a second psychotropic medication, which can increase the risk of adverse effects on fetal development. The complexities of pharmacokinetics and the interactions between different medications can pose additional risks that are not present when a mother remains on a single, stable medication.


  • 2) Potential exposure to untreated mental health issues: It is well-documented that untreated mental health conditions during pregnancy can have detrimental effects on fetal development. Conditions such as depression and anxiety can lead to complications, including low birth weight, preterm birth, and developmental delays. By changing medications, there is a risk of exacerbating these mental health issues, which can ultimately harm both the mother and the fetus.


However, it is essential to note that there are exceptions to this general guideline, with one of the most significant being the use of Depakote (valproic acid). Research has shown that there is no safe amount of Depakote that can be used during pregnancy. The risks associated with this medication are considerable, as it has been linked to a range of serious birth defects and developmental disorders. Consequently, if a woman is prescribed Depakote or valproic acid, healthcare providers typically require that she takes additional precautions, such as using effective birth control methods to prevent pregnancy and taking 4-5 mg of folic acid daily to mitigate some of the risks associated with neural tube defects.

It is crucial to clarify that this information is primarily relevant within the context of psychiatric treatment. A neurologist treating a patient with a seizure disorder may have a different perspective based on the evidence available regarding the management of seizure medications during pregnancy. The approach to treatment can vary significantly depending on the specific medical conditions being addressed and the individual patient's circumstances. Therefore, collaborative care involving both psychiatrists and obstetricians is often recommended to ensure that both the mental health needs of the mother and the safety of the fetus are adequately addressed.



Like, Share, Follow and Subscribe for more original content by Tally Reproductive Psychiatrist, Jamie Lee Sorenson, MD on Women’s Mental Health and the Bendy Boy Mom life.


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Disclaimer: Posts are for education and entertainment only. No medical advice given. This information is for general knowledge and not meant to diagnose or treat any conditions.


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